Top 5 Best Folate Supplements in 2025

Vitamin B9, also referred to as folate, is a vital nutrient that is critically involved in numerous bodily processes. It’s notably significant for expectant mothers as it helps avert birth abnormalities in the brain and spine of the baby. Although many foods contain folate, certain individuals may need to enhance their consumption with a folate supplement.

When it comes to choosing the best folate supplement, there are a few critical things to consider. First and foremost, it’s important to choose a supplement that contains the active form of folate, which is called L-methylfolate. This form of folate is more easily absorbed by the body than other forms, making it a more effective option.

Another important factor to consider is the dosage of the supplement. The recommended daily intake of folate varies depending on age, gender, and other factors, so it’s important to choose a supplement that provides the appropriate amount of folate for your needs.

We spent hours researching and testing various folate supplements to identify the best options on the market. In the following sections, we’ll share our top picks and provide a detailed analysis of each product.

Best Folate Supplements

We understand that getting the recommended daily intake of folate can be a challenge, especially for those who follow a vegetarian or vegan diet. That’s why we’ve researched and tested various folate supplements available on Amazon to bring you our top picks. Our list includes supplements that are vegan-friendly, gluten-free, and non-GMO. Whether you’re pregnant, looking to support your heart health, or simply want to ensure you’re getting enough folate, we’ve got you covered.

1. Thorne 5-MTHF 1mg

If you’re looking for a folate supplement that supports healthy methylation, nerve function, and cardiovascular health, Thorne 5-MTHF 1mg could be a good choice.

Pros

• Provides nutritional cofactors for optimal homocysteine metabolism, which supports cardiovascular health.
• Supports healthy blood vessel and nerve function, which helps maintain a healthy outlook.
• Chosen by champions and trusted by 100+ pro teams, so you know it’s a quality product.

Cons

• Some users may experience side effects like fatigue or nausea, especially when first starting to use the supplement.
• May be more expensive than other folate supplements on the market.
• Capsules are unflavored, which may be a downside for some users who prefer a flavored supplement.

We’ve been using Thorne 5-MTHF 1mg for a few weeks now and have noticed some positive effects. We feel more alert and energized, and our mood has improved. The capsules are small and easy to swallow, which is a plus. However, we did experience some mild nausea when first starting to use the supplement, which is a common side effect.

Overall, we think Thorne 5-MTHF 1mg is a solid choice for anyone looking for a high-quality folate supplement that supports healthy methylation, nerve function, and cardiovascular health. While it may be more expensive than other options, the fact that it’s trusted by pro teams and backed by research from Mayo Clinic makes it worth considering.

2. Pure Encapsulations Folate 1000

We highly recommend Pure Encapsulations Folate 1000 for those looking for a high-quality folate supplement that is hypoallergenic and free from unnecessary additives.

Pros

• Naturally Occurring Folate: Folate 1,000 provides Metafolin (L-5-MTHF), the naturally occurring, universally metabolized form of folate.*
• Cellular Health: Adequate folate intake may provide significant cardiovascular, cellular and neural support.*
• Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.

Cons

• May be more expensive than other brands
• Unflavored capsules may not be ideal for those who have trouble swallowing pills
• Some users may prefer a supplement with additional vitamins or minerals

Pure Encapsulations Folate 1000 is a high-quality supplement that provides naturally occurring folate in the form of Metafolin (L-5-MTHF). This supplement is hypoallergenic and free from unnecessary additives, making it a great choice for those with allergies or sensitivities.

In addition to supporting fetal development, folate has also been associated with cellular, cardiovascular, and neurological health. Adequate folate intake may provide significant cardiovascular, cellular, and neural support.

We appreciate the quality of Pure Encapsulations supplements, which are made with only premium ingredients sourced from trusted suppliers and guided by their nutritional experts. Each supplement is carefully manufactured and tested to verify its potency and purity.

While Pure Encapsulations Folate 1000 may be more expensive than other brands, we believe the quality of this supplement justifies the cost. However, some users may prefer a supplement with additional vitamins or minerals, and the unflavored capsules may not be ideal for those who have trouble swallowing pills.

Overall, we highly recommend Pure Encapsulations Folate 1000 for those looking for a high-quality folate supplement that is hypoallergenic and free from unnecessary additives.

3. Pure Encapsulations B12 Folate

If you are looking for a premium folate supplement, Pure Encapsulations B12 Folate might be the right choice for you.

Pros

• Provides metabolism support
• Supports nervous system and cognitive function
• Free from common allergens, artificial or unnecessary ingredients, and GMOs

Cons

• May cause headaches in some individuals
• May not be suitable for those who prefer flavored supplements
• Not suitable for vegans

We have been using Pure Encapsulations B12 Folate for a few months now, and it has been a great addition to our supplement routine. The capsules are small and easy to swallow, and we have not experienced any adverse side effects.

One of the things we love about this supplement is that it provides metabolism support. The combination of vitamin B12 and folate helps convert carbohydrates into energy and break down proteins in the body, which is essential for maintaining a healthy metabolism.

Another great benefit of Pure Encapsulations B12 Folate is that it supports nervous system and cognitive function. Folate is essential for fetal neural development, while vitamin B12 is an important nutrient for memory and cognitive support. We have noticed an improvement in our cognitive function since we started taking this supplement.

We also appreciate that Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs. This supplement is unflavored, which may not be suitable for those who prefer flavored supplements.

However, some individuals may experience headaches as a side effect of taking this supplement. Additionally, Pure Encapsulations B12 Folate is not suitable for vegans as it contains gelatin.

Overall, we highly recommend Pure Encapsulations B12 Folate to anyone looking for a high-quality folate supplement that provides metabolism support, supports nervous system and cognitive function, and is free from common allergens, artificial or unnecessary ingredients, and GMOs.

4. Doctor’s Best Fully Active Folate

We highly recommend Doctor’s Best Fully Active Folate for anyone looking for a high-quality folate supplement.

Pros

• Provides MTHF, the most directly required folate form for DNA regulation and metabolic processes
• Includes vitamin C for added stability
• Gluten-free, non-GMO, and vegan

Cons

• Must be available during product delivery to prevent damage from heat or sunlight
• Label images may vary
• Products may arrive warm during summer months

Doctor’s Best Fully Active Folate is an excellent choice for those looking to support their folate levels. The MTHF form of folate is the most directly required for DNA regulation and metabolic processes, making it an ideal choice for those looking to support their overall health. Additionally, the inclusion of vitamin C helps to ensure the stability of the product.

While the product is gluten-free, non-GMO, and vegan, it is important to note that customers must be available during product delivery to prevent melting or damage from heat or sunlight. Additionally, label images may vary, and the product may arrive warm during the summer months.

Overall, we highly recommend Doctor’s Best Fully Active Folate for anyone looking for a high-quality folate supplement.

5. Thorne 5-MTHF 5mg Supplement

We highly recommend the Thorne 5-MTHF 5mg Supplement for anyone looking for a high-quality folate supplement.

Pros

• The supplement supports healthy methylation, which is essential for overall health and wellbeing.
• It also supports a healthy outlook and healthy blood vessel and nerve function.
• The nutritional cofactors in the supplement support cardiovascular health, making it a great choice for those looking to improve their heart health.

Cons

• The supplement can be a bit pricey compared to other folate supplements on the market.
• The capsules are quite large, which may be difficult for some people to swallow.
• The supplement may not be suitable for those with certain medical conditions, so it’s important to consult with a healthcare professional before taking it.

This supplement has been a game-changer for us. We have noticed a significant improvement in our overall health and wellbeing since starting to take it. The supplement is easy to take and doesn’t cause any unpleasant side effects.

We appreciate that Thorne is a trusted brand that is chosen by champions and trusted by over 100 professional teams. We also like that Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content, and is a proud partner of 11 U.S. Olympic Teams.

Overall, we highly recommend the Thorne 5-MTHF 5mg Supplement to anyone looking for a high-quality folate supplement that supports healthy methylation, cardiovascular health, and overall wellbeing.

Buying Guide

When it comes to choosing the best folate supplement, there are a few key features to consider. Here are some factors to keep in mind when making your selection:

Form of Folate

The first thing to consider is the form of folate in the supplement. Folate supplements are available in several forms, including folic acid, L-methylfolate, and folinic acid. Folic acid is the synthetic form of folate and is the most commonly used form in supplements. L-methylfolate is the active form of folate that the body can use immediately, making it a good choice for those with a genetic mutation that impairs folate metabolism. Folinic acid is another form of folate that is often used in supplements and is particularly helpful for those with certain medical conditions.

Dosage

The dosage of folate is also an important consideration. The recommended daily intake of folate for adults is 400-800 mcg, but some people may require higher doses due to certain medical conditions or medications. Be sure to consult with your healthcare provider to determine the appropriate dosage for your needs.

Additional Ingredients

Some folate supplements may contain additional ingredients, such as vitamins B12 and B6, which can work together with folate to support overall health. However, it’s important to be aware of any potential interactions or side effects of these additional ingredients, especially if you are taking other medications or have underlying medical conditions.

Quality

Finally, it’s important to choose a high-quality folate supplement from a reputable manufacturer. Look for supplements that have been independently tested for purity and potency, and that are free from harmful contaminants. You may also want to consider supplements that are certified by third-party organizations, such as NSF International or USP.

By considering these factors, you can choose the best folate supplement to meet your individual needs and support your overall health and well-being.

Frequently Asked Questions

What are the top-rated methylfolate supplements for prenatal care?

We recommend seeking advice from a healthcare professional before taking any supplements during pregnancy. However, some of the top-rated methylfolate supplements for prenatal care include Thorne Research – 5-MTHF 1mg, Seeking Health Optimal Prenatal Chewable, and Jarrow Formulas Methyl Folate.

Which form of folate is most recommended for enhancing absorption?

L-methylfolate, also known as 5-MTHF, is the most recommended form of folate for enhancing absorption. This is because it is the active form of folate that the body can readily use.

What are the advantages of L-methylfolate supplements for managing depression?

Studies have suggested that L-methylfolate supplements may help manage depression by increasing the production of neurotransmitters such as serotonin, dopamine, and norepinephrine. Additionally, L-methylfolate has been shown to enhance the effectiveness of antidepressant medication.

What are the most trusted brands of folic acid supplements according to consumer reviews?

Some of the most trusted brands of folic acid supplements according to consumer reviews include Nature Made Folic Acid, Solgar Folate, and Garden of Life Vitamin Code Raw Folate.

How does natural folate compare to synthetic folic acid in terms of health benefits?

Natural folate and synthetic folic acid have similar health benefits. However, natural folate is found in whole foods and is easier for the body to absorb. Synthetic folic acid is commonly added to fortified foods and supplements and may not be as readily absorbed by the body.

What dosage of folic acid is considered safe and effective for daily supplementation?

The recommended daily dosage of folic acid for most adults is 400-800 micrograms. Pregnant women are advised to take 600-800 micrograms of folic acid daily to help prevent birth defects. However, it is important to consult with a healthcare professional before starting any new supplement regimen.

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