Top 5 Best Heartburn Acid Reflux Otc Medications in 2025

Heartburn and acid reflux are frequent digestive issues that can lead to uneasiness and anguish. Although there are prescribed medicines accessible, several individuals opt for over-the-counter (OTC) remedies for symptom alleviation. This article will be highlighting the most effective OTC medicines for heartburn and acid reflux.

The most common types of OTC medications for heartburn and acid reflux are antacids, H2 blockers, and proton pump inhibitors (PPIs). Antacids work by neutralizing stomach acid, while H2 blockers and PPIs reduce the amount of acid produced by the stomach. Each type of medication has its own benefits and drawbacks, and the choice of medication will depend on the severity and frequency of the symptoms.

When choosing an OTC medication for heartburn and acid reflux, it is important to consider the duration of the medication’s effect, any potential side effects, and any interactions with other medications. Additionally, it is important to follow the recommended dosage instructions and not to exceed the maximum daily dose.

In this article, we will be reviewing and comparing the top OTC medications for heartburn and acid reflux, taking into account their effectiveness, safety, and ease of use. Whether you suffer from occasional heartburn or chronic acid reflux, we have researched and tested the best options to help you find relief.

Best Heartburn & Acid Reflux OTC Medications

If you suffer from heartburn or acid reflux, you know how uncomfortable and disruptive it can be to your daily life. Fortunately, there are many over-the-counter medications available to help alleviate these symptoms. In this article, we’ve compiled a list of the best heartburn and acid reflux OTC medications to help you find relief quickly and easily. Our team has researched and tested these products to ensure they are effective and safe for use. Read on to find the best option for your needs.

1. Alka-Seltzer Extra Strength Heartburn Relief Chews

Alka-Seltzer Extra Strength Heartburn Relief Chews are a great choice for on-the-go antacid relief of heartburn, acid indigestion, or sour stomach. These chews provide fast, powerful antacid relief of a trio of unpleasant symptoms in tasty assorted fruit flavors.

Pros

• Fast-acting relief
• Conveniently sized for on-the-go use
• Non-chalky and non-gritty

Cons

• May not work for severe heartburn
• May cause constipation or diarrhea
• May not be suitable for children under 12 years old

We highly recommend Alka-Seltzer Extra Strength Heartburn Relief Chews for those who suffer from occasional heartburn or acid indigestion. These chews are fast-acting and conveniently sized for on-the-go use, making them a great choice for those who need relief while out and about.

In addition to their convenience, these chews are also non-chalky and non-gritty, making them easy to take and swallow. However, they may not work for severe heartburn and may cause constipation or diarrhea in some individuals. Additionally, they are not suitable for children under 12 years old.

Overall, Alka-Seltzer Extra Strength Heartburn Relief Chews are a trusted and effective choice for those in need of fast-acting heartburn relief.

2. Zantac 360 Maximum Strength Tablets

If you’re looking for fast-acting and long-lasting heartburn relief, then Zantac 360 Maximum Strength Tablets might be a good option for you.

Pros

• Zantac 360 with Triple Action: prevents, relieves, and lasts
• Starts working in as little as 15 minutes
• Reduces stomach acid production for up to 12 hours

Cons

• Acid control does not correlate with symptom relief
• Some users may experience side effects such as headache, constipation, or diarrhea
• Only comes in one dosage strength (20 mg)

We’ve been using Zantac 360 Maximum Strength Tablets for a few weeks now and have found that it works quickly to relieve heartburn symptoms. The tablet is easy to swallow and doesn’t have a bad taste. We also appreciate that it can be taken to prevent heartburn before a meal.

However, it’s important to note that acid control does not necessarily mean symptom relief. While Zantac 360 can reduce stomach acid production, it may not completely alleviate all heartburn symptoms. Additionally, some users may experience side effects such as headache, constipation, or diarrhea.

Overall, we would recommend giving Zantac 360 Maximum Strength Tablets a try if you’re looking for a fast-acting and long-lasting heartburn medication. As always, be sure to follow the directions on the package and consult with a healthcare professional if you have any concerns.

3. Nexium 24HR ClearMinis Acid Reducer Heartburn Relief

If you want a heartburn medication that is easy to swallow and provides complete protection from heartburn, then Nexium 24HR ClearMinis Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium is the perfect choice for you.

Pros

• The mini capsules contain all the power of Nexium 24HR Frequent Heartburn Protection in a pill over 1/3 smaller to be easier to swallow.
• Just one clear mini capsule daily provides 24 hour relief, letting you get through your day and sleep restfully at night without heartburn interruptions.
• Esomeprazole magnesium delayed-release capsules shut down stomach’s active acid pumps to treat frequent heartburn all day and all night.

Cons

• May take 1-4 days to reach full effect.
• Do not take for more than 14 days or more often than every 4 months unless directed by a doctor.
• Not for immediate relief.

Nexium 24HR ClearMinis Acid Reducer Heartburn Relief Capsules are a proton pump inhibitor (PPI) that contain a delayed release formula with esomeprazole magnesium to block acid at the source for complete heartburn protection. This medication may take 1 to 4 days to reach full effect, but relief lasts 24 hours.

One of the best things about Nexium 24HR ClearMinis is that they are approximately 38 percent smaller than the original Nexium 24HR capsules, which makes them easier to swallow. They are also perfect for people who are always on the go and want to carry their medication with them.

Nexium has reduced the amount of plastic used by 24 tons in 2022. Since 2021, Nexium has reduced its plastic usage by 15%. By changing its manufacturing technology, Nexium now uses 15% less plastic. This is a great initiative by the company to reduce plastic waste and protect the environment.

Overall, if you suffer from frequent heartburn, Nexium 24HR ClearMinis Acid Reducer Heartburn Relief Capsules are a great choice. They are easy to swallow, provide complete protection from heartburn, and are perfect for people who are always on the go.

4. Terry Naturally Heartburn Rescue – 30 Softgels

We highly recommend Terry Naturally Heartburn Rescue for anyone looking for a natural and effective solution to occasional heartburn, acid indigestion, and upset stomach.

Pros

• Heartburn Rescue provides relief of occasional heartburn, acid indigestion, and upset stomach.
• The synergistic blend of d-limonene and sea buckthorn oil provides support for healthy digestive function and mucous membrane health while soothing the gastrointestinal tract.
• Say goodbye to your heartburn! Just take one Heartburn Rescue each day for lasting relief from occasional heartburn.

Cons

• The pill is large and may be hard to swallow.
• It is not as fast as “normal” heartburn medicine.
• It may not work for everyone.

Terry Naturally Heartburn Rescue is a natural and effective solution to occasional heartburn, acid indigestion, and upset stomach. The synergistic blend of d-limonene and sea buckthorn oil provides support for healthy digestive function and mucous membrane health while soothing the gastrointestinal tract. It is easy to use, just take one Heartburn Rescue each day for lasting relief from occasional heartburn.

The product is manufactured to strict Good Manufacturing Practices (cGMP) set by the FDA and is produced with the highest quality ingredients. It is non-GMO and gluten-free, making it a healthy choice for anyone looking for a natural and effective solution to occasional heartburn.

Terry Naturally Heartburn Rescue is a great alternative to traditional heartburn medicine. It is natural, effective, and safe for long-term use. It may not work for everyone, but it is definitely worth a try if you are looking for a natural and effective solution to occasional heartburn.

5. Amazon Basic Care Maximum Strength Famotidine Tablets

If you’re looking for an affordable and effective way to relieve heartburn and acid reflux, Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg is the way to go.

Pros

• Provides quick relief from heartburn
• Prevents heartburn from occurring when taken ahead of time
• Lasts up to 12 hours

Cons

• May not work for severe cases of heartburn
• Some users may experience side effects such as headache or dizziness
• Not recommended for children under 12 years of age

We’ve been using Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg for a while now and have found it to be a reliable and effective way to manage heartburn and acid reflux. The tablets are easy to swallow and provide quick relief from heartburn symptoms. We’ve also found that taking a tablet 10 to 60 minutes ahead of time can prevent heartburn from occurring when we know we’ll be eating or drinking certain foods and beverages that tend to trigger acid indigestion.

One of the best things about Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg is that it lasts up to 12 hours, so we don’t have to worry about taking another tablet for a while after the initial dose. It’s also gluten-free, which is great for those with dietary restrictions.

While Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg works well for us, it may not be effective for severe cases of heartburn. Some users may also experience side effects such as headache or dizziness, so it’s important to talk to a doctor before using this product. Additionally, it is not recommended for children under 12 years of age.

Overall, if you’re looking for an affordable and reliable way to manage heartburn and acid reflux, Amazon Basic Care Maximum Strength Famotidine Tablets 20 mg is definitely worth trying.

Buying Guide

When it comes to choosing the best heartburn and acid reflux OTC medication, there are several factors to consider. Here are some features to look for that can help you make an informed decision:

Active Ingredients

One of the most important factors to consider when choosing an OTC medication for heartburn and acid reflux is the active ingredient. There are several different types of active ingredients, each with their own strengths and weaknesses. Some common active ingredients include:

• Antacids: These work by neutralizing stomach acid and can provide fast relief. However, they may not be effective for long-term relief.
• H2 blockers: These reduce the amount of acid produced in the stomach and can provide relief for up to 12 hours. They may take longer to work than antacids.
• Proton pump inhibitors (PPIs): These are the most powerful type of OTC medication for heartburn and acid reflux. They work by blocking acid production in the stomach and can provide relief for up to 24 hours. However, they may take several days to start working.

Dosage Form

OTC heartburn and acid reflux medications come in several different dosage forms, including tablets, capsules, liquids, and chewable tablets. Consider which form is most convenient for you and which is easiest for you to take.

Price

OTC heartburn and acid reflux medications can vary widely in price. While price should not be the only factor you consider, it is important to find a medication that fits within your budget. Look for generic versions of medications, which can be just as effective as brand-name versions but are often less expensive.

Side Effects

Like all medications, OTC heartburn and acid reflux medications can have side effects. Common side effects include constipation, diarrhea, and headache. Make sure to read the label carefully and talk to your doctor or pharmacist if you have any concerns about potential side effects.

By considering these factors, you can choose the best OTC medication for your heartburn and acid reflux symptoms. Remember to always read the label carefully and talk to your doctor or pharmacist if you have any questions or concerns.

Frequently Asked Questions

What are the top recommended over-the-counter medications for acid reflux relief?

There are several over-the-counter medications that can provide relief from acid reflux symptoms. Some of the most popular options include antacids, H2 blockers, and proton pump inhibitors (PPIs). Antacids like Tums and Rolaids work by neutralizing stomach acid, while H2 blockers like Pepcid and Zantac reduce the amount of acid your stomach produces. PPIs like Prilosec and Nexium are the most potent and work by blocking the production of stomach acid altogether.

Which OTC antacids are considered safe for long-term management of heartburn?

Antacids are generally considered safe for long-term use, but it’s important to choose a product that doesn’t contain aluminum or magnesium. These ingredients can cause constipation or diarrhea if used in excess. Calcium carbonate-based antacids like Tums and Rolaids are a good choice for long-term management of heartburn because they are effective and have few side effects.

What non-prescription remedies are effective for treating heartburn and acid reflux?

In addition to over-the-counter medications, there are several non-prescription remedies that can help alleviate heartburn and acid reflux symptoms. Ginger tea, chamomile tea, and licorice root tea are all natural remedies that can help soothe the digestive system. Apple cider vinegar and baking soda can also be effective, but it’s important to use them in moderation and under the guidance of a healthcare provider.

Are there any over-the-counter medicines that can reduce stomach acidity effectively?

Yes, there are several over-the-counter medicines that can effectively reduce stomach acidity. H2 blockers like Pepcid and Zantac can reduce stomach acid production, while PPIs like Prilosec and Nexium can block acid production altogether. Antacids like Tums and Rolaids can also provide relief by neutralizing stomach acid.

What beverages provide relief from heartburn symptoms?

Certain beverages can help alleviate heartburn symptoms. Ginger tea, chamomile tea, and licorice root tea can all help soothe the digestive system and reduce inflammation. Aloe vera juice and coconut water can also be effective in reducing heartburn symptoms.

Which over-the-counter medication is recognized as the most potent for severe acid reflux?

PPIs like Prilosec and Nexium are recognized as the most potent over-the-counter medications for severe acid reflux. These medications work by blocking the production of stomach acid altogether, providing long-lasting relief from symptoms. However, it’s important to use these medications under the guidance of a healthcare provider, as they can have potential side effects and interactions with other medications.

We independently select all products and services. This article was written by a third-party company. If you click through links we provide, we may earn a commission.